Most published medical research is false! In 2005, in a landmark paper viewed well over a million times, John Ioannidis explained in PLOS Medicine why most published research findings are false. To coincide with PLOS Medicine’s 10th anniversary he responds to the challenge of this situation by suggesting how the research enterprise could be improved.
Research, including medical research, is subject to a
range of biases which mean that misleading or useless work is sometimes pursued
and published while work of value is ignored. The risks and rewards of academic
careers, the structures and habits of peer reviewed journals, and the way
universities and research institutions are set up and governed all have
profound effects on what research scientists undertake, how they choose to do
it and, ultimately, how patients are treated. Perverse incentives can lead
scientists to waste time producing and publishing results which are wrong or
useless. Understanding these incentives and altering them provides a potential
way for drastically re-shaping research to improve in medical knowledge.........“The achievements of science are amazing yet the majority
of research effort is currently wasted,” asserts Ioannidis. He calls for
testing interventions to improve the structure of scientific research, and
doing so with the rigor normally reserved for testing drugs or hypotheses......To Read More.....
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